![]() In addition, Mentha arvensis has been used to prepare infusions, decoctions, and distillates, which are liquid extracts obtained through different methods of extraction. ![]() It has been incorporated into various food preparations as a flavor enhancer, utilized as a garnish to add visual appeal to dishes, and used in the production of herbal teas. Mentha arvensis, commonly known as the wild mint, has been utilized by humans for its flavoring properties, as a decorative element, and for its medicinal benefits since ancient times. Particularly, Luteolin and Rosmarinic acid were identified as the top contenders for potential bioactivity with acceptable drug-like properties. The results of this study suggest that the Mentha arvensis extract possesses potent pharmacological potentials, particularly in terms of antibacterial, anti-diabetic, and cytotoxic effects. Furthermore, Molecular docking studies further demonstrated that both compounds have strong potential to inhibit the active sites of therapeutically relevant enzymes involved in Diabetes, Bacterial infections, and Cancer. Finally, In-silico methods demonstrated that the Luteolin and Rosmarinic acid exhibit acceptable drug-like characteristics. The growth of HepG2 cells was observed to be significantly suppressed upon treatment with extracts obtained from Mentha arvensis. Mentha arvensis has demonstrated a greater degree of efficacy in inhibiting α-glucosidase, with an inhibition rate of 58.36 ± 0.12, and in inhibiting α-amylase, with an inhibition rate of 42.18 ± 0.83. Based on antimicrobial research, it has been found that the Mentha arvensis extract shows potential activity against K. The compounds oleanolic acid, rosmarinic acid, luteolin, isoorientin, and ursolic acid have been identified through liquid chromatography mass spectrometry analysis. The potential bioactivities of extracts and lead phytocompounds, including their antibacterial, cytotoxic, and anti-diabetic effects, were evaluated. The phytochemical components of the extracts were quantified using liquid chromatography-mass spectrometry analysis. To determine the extract with the highest potential for powerful bioactivity, ethanol was used as the solvent. In this work, we have explored the phytochemical analyses and pharmacological potential of Mentha arvensis using both in silico and in vitro approaches for drug discovery. Mentha arvensis has been utilized in diverse traditional medicines as an antidiabetic, anticarcinogenic, antiallergic, antifungal, and antibacterial agent.
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